“Reducing hallucinations in schizophrenia with focused ultrasound: First-in-human clinical trial begins”

Key points

• Researchers at UCSF launched a Phase 1 trial to test LIFU targeting the caudate.
• The study uses five daily active LIFU sessions and five sham sessions per participant.
• Enrollment aims to include up to 12 participants with persistent auditory hallucinations.
• Resting-state fMRI will assess connectivity changes before and after treatment.
• Initial participants report reduced hallucinations and quieter minds during treatment.