Zombified (senescent) cells contribute to aging; therapies aim to boost immune clearance
Emerging therapies target senescent “zombie” cells by killing them or helping macrophages clear them from aging tissues.
OriginalSourceLive ScienceUnited StatesLeanCenterCredibilityPublished10:00 UTCRatings: AllSides, MBFCSourceLive ScienceUnited StatesLeanCenterCredibilityPublished10:00 UTCRatings: AllSides, MBFC
“Zombified cells may drive aging, and scientists are devising new ways to get rid of them”
Zombified (senescent) cells contribute to aging; therapies aim to boost immune clearance
Key points
- Emerging treatments seek to reverse aging signs and reduce age-related disease risk.
- Zombie cells are senescent cells that refuse to die and inflame tissues.
- Senolytics drugs can kill senescent cells, lowering inflammation and improving function in mice.
- EP2 receptor on macrophages impairs clearance of senescent cells as we age.
- Blocking EP2 or boosting macrophage energy improves aging-related outcomes in studies.
How it got here
Live Science publishes the article.
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10 10 Zombified (senescent) cells contribute to aging; therapies aim to boost immune clearance
Emerging therapies target senescent “zombie” cells by killing them or helping macrophages clear them from aging tissues.