Mpox continues to circulate in the United States and may become endemic.
Mpox cases declined after the 2022 surge but continue circulating in the United States, with thousands recorded in 2024 and 2025.
OriginalSourceLive ScienceUnited StatesLeanCenterCredibilityPublished10:00 UTCRatings: AllSides, MBFCSourceLive ScienceUnited StatesLeanCenterCredibilityPublished10:00 UTCRatings: AllSides, MBFC
“'Mpox has not disappeared': Why the infectious disease is still spreading in the US and may be here to stay”
Mpox continues to circulate in the United States and may become endemic.
Key points
- Mpox outbreaks surged in 2022, then declined but did not disappear in the US.
- A August report recorded 2,800 cases in 2024 and over 2,500 in 2025.
- Most samples stem from the 2022 outbreak strain, indicating persistence of transmission.
- Experts attribute continued spread to insufficient vaccination and other factors.
- Public health efforts have waned, risking elimination of mpox in the US.
How it got here
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10 10 Mpox continues to circulate in the United States and may become endemic.
Mpox cases declined after the 2022 surge but continue circulating in the United States, with thousands recorded in 2024 and 2025.